Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation.
RatOtherSprague-DawleyMalen = 96 rats, n = 24 per group across four groups, with n = 4 to…Intraperitoneal, and intrathecal via the L4-5 intervertebral spaceIntraperitoneal 12.5 mg/kg (50 mg/mL in saline); intratheca…Intrathecal dose given as pretreatment with surgery performed 10 minutes later;…
Model: Left L5 spinal nerve ligation with 6-0 Dexon after removal of the left L6 transverse process, producing neuropathic pain
Intraperitoneal amitriptyline alone reduced thermal hypersensitivity to postoperative day 7, reversed Nav1.8 downregulation and reduced microglial activation by day 14. Adding intrathecal pretreatment extended the thermal benefit, attenuated mechanical hypersensitivity at day 7, reduced Nav1.3 upre…
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