Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury.

PMID 22708918 ↗2012Mixed findings

Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury.

RatSpinal cord injuryContusionF344 (Fischer 344)Femalen = n=10 per group, three groupsSpinal superfusion200 nM3 h after injury

Model: Moderate contusive spinal cord injury at thoracic T8

No significant difference in BBB score against controls, but BBB subscore analysis showed significant improvement in foot positioning, trunk stability and tail clearance. No gross improvement in preserved white or grey matter, though greater numbers of surviving neurons were present adjacent to the…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury.

Evidence by therapy association

Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury.