Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice.

Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice.

Model: L-arginine induced acute necrotising pancreatitis

Serum thrombopoietin was raised in necrotising pancreatitis. Thrombopoietin administration worsened acinar necrosis and pancreatitis associated lung injury, whereas anti-thrombopoietin antibody reduced acinar necrosis and attenuated lung injury, with effects on acinar regeneration and apoptosis.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.