Normal tissues toxicities triggered by combined anti-angiogenic and radiation therapies: hurdles might be ahead.
MouseRadiationC57BL/6 (C57B6)Femalen = 370 mice total, more than 10 per point; n=80 in the repeate…Beginning 24 h before irradiation
Model: Radiation-induced normal tissue injury: 12 Gy total body irradiation for intestinal and colonic ulceration (with intra-rectal TNBS 150 mg/kg in one arm), 16.5 Gy localised oral irradiation for mucositis, and 19 Gy thoracic irradiation or bleomycin 40 mg/kg for lung fibrosis
Combining anti-VEGF antibody with irradiation enhanced intestinal damage with severe epithelial ulceration and necrotic glands, had no adverse impact on oral mucositis, and dramatically worsened lung fibrosis induced by both bleomycin and irradiation, with perivascular inflammatory patches and vasc…
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