The severity of brain damage determines bone marrow stromal cell therapy efficacy in a traumatic brain injury model.
RatTBIWeight-drop / impact-accelerationWistarFemaleIntracerebral injection into injured brain tissueTwo months after injury
Model: Weight-drop impact traumatic brain injury, chronically established (treated 2 months after injury)
Significant functional improvement was seen when BMSC were injected into animals with moderate brain damage, but no significant improvement was found in animals with severe functional deficits compared with controls, suggesting injury severity determines cell therapy efficacy in chronically establi…
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