Ziprasidone attenuates brain injury after focal cerebral ischemia induced by middle cerebral artery occlusion in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMale5 mg/kg acute; 2.5 mg/kg subchronicAcute treatment at the time of ischemia; subchronic treatment continued for 7 d…
Model: Middle cerebral artery occlusion for 1 h followed by reperfusion
Acute 5 mg/kg and subchronic 2.5 mg/kg ziprasidone significantly reduced infarct size versus vehicle. Acute treatment improved neurological function dose-dependently, and subchronic treatment gave more rapid recovery from functional deficits, prevented severe loss of neuronal marker intensity and a…
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