The effects of acute voluntary wheel running on recovery of function following medial frontal cortical contusions in rats.
RatTBIControlled cortical impactLong-Evansmalen = 31 rats across the 2 x 2 lesion by treatment designFree access to running wheels in the home environmentImmediately after injury (acute)
Model: Bilateral cortical contusion of the medial frontal cortex, with sham operated controls, following acquisition of a stop-signal reaction time task
Bilateral medial frontal contusion impaired performance on the complex task, and acute voluntary wheel running started immediately after injury exacerbated rather than reduced the deficit; performance did not return to the level of injured rats without wheels until day 13 after injury.
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