Improvement of skin quality using a new collagen scaffold in acute burns and reconstructive surgery: an in vivo evaluation of split skin graft transplantation in a rat model.
RatWoundLewismalen = 28 full-thickness wounds, with the collagen cell carrier ap…Topical, applied as an underlayment beneath the split skin graftAt the time of grafting
Model: Full-thickness skin wounds covered with split-thickness skin grafts in rats, modelling acute burn and reconstructive surgical defects
Grafts supplemented with the collagen cell carrier showed significantly better gross elasticity and viscoelasticity than grafts alone from day 60 to the end of the 80 day measuring period, with no histological evidence of inflammation, adverse host tissue reaction or scar formation.
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