Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model.
RatOtherWistarmaleIntraperitonealAcute administration after sciatic nerve injury
Model: Chronic constriction injury of the sciatic nerve producing neuropathic pain
Amitriptyline and clomipramine produced antinociceptive effects after chronic constriction injury whereas desipramine did not. The effect of amitriptyline, but not clomipramine, was augmented by aminoguanidine, and amitriptyline inhibited iNOS mRNA and protein expression in cerebellum and hippocamp…
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