Lithium reduces BACE1 overexpression, beta amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury.

Lithium reduces BACE1 overexpression, beta amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury.

Model: Controlled traumatic brain injury in mice

Lithium attenuated the injury induced increases in beta amyloid load, amyloid precursor protein accumulation and BACE1 overexpression at 3 days, reduced thalamic Tau phosphorylation, and significantly improved spatial learning and memory in the Y-maze and Morris water maze alongside greater hippoca…

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