The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection.
RatOtherLewismaleIntra-articular injectionSingle dose, amount not statedGiven to exercised anterior cruciate ligament transected joints in the 5 week e…
Model: Anterior cruciate ligament transection of the rat knee, with or without forced joint exercise, as a model of post-traumatic cartilage degeneration
Forced joint exercise after anterior cruciate ligament transection reduced cartilage lubricin expression at 3 weeks (p<0.001), raised OARSI scores at 5 weeks (p<0.001) and increased caspase-3 staining. Intra-articular lubricin significantly increased cartilage lubricin gene expression (p<0.001) and…
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