Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury.
MouseChemical/toxinC57BL/6 wild-typeMalen = Acute model n = 6 per group (sacrificed at 24 or 48 h); chr…Intraperitoneal10 microgram daily in the chronic fibrosis model; dose not…Acute model: administered before, then 12 and 24 h after CCl4; chronic model: a…
Model: Carbon tetrachloride (CCl4) induced acute liver injury (single i.p. injection, 0.8 mg/kg bodyweight) and chronic liver fibrosis (0.6 mg/kg bodyweight in 1:1 mineral oil, twice weekly for 6 weeks)
[44AANA47]-CCL5 reduced ALT at 48 h after CCl4 (p < 0.01, no difference at 24 h), reduced hepatic necrosis, and significantly reduced CD45+ immune cell infiltration at 24 h (p < 0.01) with lower TNF, IL-1 and CCL3 mRNA. In the chronic model it reduced Sirius red positive area (p < 0.01) and hepatic…
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