Suppressive effect of recombinant human thioredoxin on ultraviolet light-induced inflammation and apoptosis in murine skin.
MouseRadiationC57BL/6 wild-type and thioredoxin-transgenicFemaleIntraperitoneal
Model: Ultraviolet-B irradiation of skin causing acute inflammation and keratinocyte apoptosis
Ear swelling after UV-B was significantly reduced in TRX-transgenic mice compared with wild type. Intraperitoneal recombinant human thioredoxin reduced acute skin erythema and swelling, reduced neutrophil and lymphocyte infiltration and vessel calibre, significantly reduced sunburn cells, activated…
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