Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.
MouseChemical/toxinC57BL/6 wild-type, C3-/-, factor B-/- and C1q/MBL double-deficientIntraperitoneal0.25 mg per injectionTherapeutic protocol beginning on day 5, on replacement of DSS with normal drin…
Model: Acute dextran sulfate sodium (DSS) induced colitis, 5% w/v in drinking water ad libitum for 5 days, with or without a 7-day recovery period on normal water
C3-/- and factor B-/- mice were protected at day 5 while C1q/MBL-/- mice had worse disease, but all complement-deficient mice died during the recovery period (C1q/MBL-/- by day 2, C3-/- and fB-/- by day 5) with raised serum endotoxin; antibiotics rescued 100% of them. Therapeutic CR2-Crry and CR2-f…
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