Protection against acute radiation-induced lung injury: a novel role for the anti-angiogenic agent Endostar.
MouseRadiationC57BL/6Femalen = 108 female mice randomised into 4 groups (n = 27 per group)…Intraperitoneal7.75 ml/kg
Model: Radiation-induced lung injury from a single external thoracic irradiation (6 MV X-ray, 12 Gy)
Irradiation induced interstitial oedema and a significant increase in pulmonary inflammatory cells (P < 0.05) with a time-dependent rise in TGF-beta1 mRNA and immunoreactivity. Endostar significantly attenuated the increase in inflammatory cells and the elevation of TGF-beta1 expression (P < 0.05),…
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