Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation.
MouseRadiationRecipients Balb/c and CD2F1; donor cells pooled from AKR, C57Bl/6 and FVB miceMaleIntravenous transfusionVarious cell doses, including 5 million cells (dose-reducti…From 24 h up to 7 days after irradiation
Model: Lethal total body irradiation with 60Co gamma rays (9.2 Gy and up to 15 Gy, CD2F1) or X-rays (9 Gy, Balb/c)
Cryopreserved allogeneic myeloid progenitor cells significantly improved 30-day survival in both strains after lethal irradiation. The benefit was cell-dose dependent and remained significant when administration was delayed up to 7 days, and up to 5 days at doses as high as 14 Gy.
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