LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals.
MouseRadiationC57BL/6FemaleOralFour weeks of dosing given either before, during or after irradiation
Model: Single-dose 20 Gy thoracic irradiation causing pneumonitis and pulmonary fibrosis
LY2109761 markedly reduced radiation-induced inflammation and pulmonary fibrosis and prolonged survival, suppressing canonical and non-canonical TGF-beta and BMP signalling as well as inflammatory (IL-6, IL-7R, IL-8) and proangiogenic (ID1) genes.
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