Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
RatCrushPeripheral-nerve crushSprague-DawleyMalePAR2 antagonistic peptide applied before and during injury; SQ22536 administere…
Model: Chronic compression of the dorsal root ganglion (CCD) and acute dissociation of dorsal root ganglion neurons
Pretreatment with the PAR2 antagonistic peptide prevented the increases in cAMP and PKA activity, neuronal hyperexcitability and thermal hyperalgesia, but post-treatment did not. SQ22536 given after injury successfully suppressed hyperexcitability and hyperalgesia.
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