Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-alpha.
MouseSpinal cord injuryCompressionPPAR-alpha knockout mice on 129S4/SvJae background and wild-type controls, C57BL/6n = 30 mice per experimental groupIntraperitoneal bolus10 mg/kg simvastatin dissolved in saline; PPAR-alpha antago…1 h and 6 h after injury; GW6471 given 30 min before simvastatin, and at 30 min…
Model: Extradural compression of the spinal cord at T6-T7 with an aneurysm clip of 24 g closing force via T5-T8 laminectomy
Simvastatin reduced inflammation, neutrophil infiltration, nitrotyrosine, cytokine expression, NF-kappaB activation, iNOS expression and apoptosis after spinal cord injury. The effect was weaker in PPAR-alpha knockout mice and was abolished by the PPAR-alpha antagonist GW6471, indicating PPAR-alpha…
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