Protective effect of antithrombin III against lung and myocardial injury in lower-limb ischemia-reperfusion syndrome.
RatIschaemia-reperfusionOther / unspecifiedWistarMalen = 60 male Wistar rats, 30 per group250 mg/kg30 minutes before reperfusion
Model: Lower-limb arterial occlusion for 6 hours followed by reperfusion, with remote lung and myocardial injury
Antithrombin III significantly lowered lung malondialdehyde at baseline and 30 minutes but not at 4 hours, indicating early protection against remote lung injury. No significant difference in myocardial malondialdehyde was found at any time point.
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