Human amnion epithelial cells do not abrogate pulmonary fibrosis in mice with impaired macrophage function.
MouseChemical/toxinSurfactant protein C deficient (Sftpc-/-) and wild-type (Sftpc+/+)24 hours after bleomycin exposure
Model: Bleomycin-induced lung injury and pulmonary fibrosis
In wild-type mice hAECs decreased pro-inflammatory gene expression, macrophage and neutrophil infiltration, fibrosis, collagen and alpha-smooth muscle actin and improved lung function. In Sftpc-/- mice with impaired macrophage function hAECs produced no reduction in inflammation, fibrosis or functi…
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