Delayed applications of L1 and chondroitinase ABC promote recovery after spinal cord injury.
MouseSpinal cord injuryCompressionC57BL/6FemaleIntraspinal injectionDelayed injection 3 weeks after injury
Model: Thoracic compression spinal cord injury
All treatment groups showed enhanced locomotor recovery versus AAV-GFP. L1 overexpression improved voluntary movement without body weight support, chondroitinase ABC improved body weight support during stepping, and the combination improved both, correlating with increased cholinergic, GABAergic an…
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