Effect of insulin-like growth factor blockade on hyperoxia-induced lung injury.
MouseOtherC57BL/6FemaleIntraperitonealAdministered before hyperoxia exposure
Model: Exposure to 95% hyperoxia for 88-90 hours causing acute lung injury
A12 significantly decreased bronchoalveolar lavage polymorphonuclear cell count compared with control antibody (P = 0.02) and lavage fluid from A12-treated mice showed reduced neutrophil chemotactic activity. There were no differences in CXCL1 or CXCL2.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.