Endothelial progenitor cells promote astrogliosis following spinal cord injury through Jagged1-dependent Notch signaling.
MouseSpinal cord injuryUnspecifiedNude miceFemaleTransplantation into the injured spinal cordAcute phase after injury
Transplantation of Jagged1-positive but not Jagged1-null endothelial progenitor cells increased reactive astrocytes during the acute phase, upregulated Hes5 and improved functional recovery after spinal cord injury. Jagged1-positive cells also produced strong pro-angiogenic effects alongside morpho…
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