Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model.

Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model.

Model: Dorsal full-thickness burn wounds measuring 2 x 4 cm

C1 esterase inhibitor treatment significantly reduced granulation tissue and macrophage infiltration and increased reepithelialisation in burn wounds. It also counteracted burn-induced macrophage infiltration into the ventricles and atria of the heart.

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