Inhibition of integrin alpha2beta1 ameliorates glomerular injury.
MouseChemical/toxinIntegrin alpha2-null and wild-type; BALB/c backgroundMale
Model: Adriamycin (doxorubicin) nephropathy and partial renal ablation
Integrin alpha2-null mice developed significantly less proteinuria and glomerulosclerosis in both models, and pharmacological inhibition of integrin alpha2beta1 significantly reduced adriamycin-induced proteinuria, glomerular injury and collagen deposition in wild-type mice.
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