Estrone is neuroprotective in rats after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMale0.5 mg/kg30 min after severe traumatic brain injury
Model: Controlled cortical impact to the right parietal cortex after craniotomy
Estrone reduced cortical lesion volume, neuronal injury, TUNEL positivity and beta-amyloid, and increased phospho-ERK1/2, phospho-CREB and BDNF.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.