Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.
MouseChemical/toxinCD1Malen = 6 mice per groupOral gavage in a volume of 2.5 mL/kg; intravenous for pharmacokinetics0.3 and 1 mg/kg for the gastric lesion study; 0.1-3 mg/kg (…Administered orally at the same time as indomethacin; in pain models given once…
Model: Indomethacin-induced gastric lesions, with parallel carrageenan inflammation, chronic sciatic nerve ligation and complete Freund's adjuvant arthritis models
Oral URB937 dose-dependently reversed hyperalgesia and allodynia, acted synergistically with indomethacin, and reduced the number and severity of indomethacin-induced gastric lesions.
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