Effects of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal injuries in Sprague-Dawley rats.
RatChemical/toxinSprague-DawleyMale (ulcer study); 18 males and 18 females in the acute toxicity studyn = Six rats per group, 30 rats total (ulcer study); 36 rats in…Oral250 and 500 mg/kg body weight (5 mL/kg); acute toxicity dos…60 min before ethanol administration
Model: Absolute ethanol-induced gastric mucosal ulcer (5 mL/kg by orogastric intubation)
Extract pre-treatment reduced ulcer area (72.2% inhibition at 250 mg/kg, 80.6% at 500 mg/kg, versus 92.0% for omeprazole), preserved mucus, raised superoxide dismutase and lowered malondialdehyde.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.