Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = Occlusion controls n=14, argon 50 vol% n=14, sham n=6; NMDA…Inhalation (gas mixture in a closed chamber); argon-saturated artificial cerebrospinal fluid ex vivoArgon 15 to 75 vol% (remainder oxygen 25 vol% with nitrogen…60 min after NMDA injection; 1 h after reperfusion (2 h after occlusion onset);…
Model: Intrastriatal NMDA excitotoxic injection, middle cerebral artery occlusion with reperfusion, and oxygen-glucose deprivation in acute brain slices
Post-insult argon reduced lactate dehydrogenase release, NMDA lesion size and cortical infarct volume, but increased subcortical damage and did not improve neurological outcome.
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