Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice.
MouseSpinal cord injuryUnspecifiedJcl:ICRMalen = 211 mice total; MR16-1 n=85, rat IgG n=85, saline n=25, sha…Intraperitoneal50 microgram per gram body weightImmediately after injury
Model: Thoracic spinal cord injury after laminectomy
MR16-1 increased spared myelin, axonal markers and Basso Mouse Scale scores (5.0 +/- 0.3 versus 2.8 +/- 0.3), lowered Th1 cytokines and promoted M2 macrophages.
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