Role of sphingomyelin synthesis in pulmonary endothelial cell cytoskeletal activation and endotoxin-induced lung injury.
MouseEndotoxin/LPSPre-treatment before lipopolysaccharide challenge
Model: Bacterial lipopolysaccharide-induced acute lung injury
D609 pre-treatment attenuated lipopolysaccharide-induced lung injury and endothelial barrier disruption, indicating a protective role for sphingomyelin synthase inhibition.
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