Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.
RatOtherSprague-DawleyMalen = n=6 per group across five groupsIntravenous via femoral venous catheter0.5 x 10^6 cells in 500 microlitre per transfusion, 1.5 x 1…1, 3 and 5 h after carotid artery injury
Model: Balloon endoluminal injury of the right carotid artery with neointima formation
Interleukin-8 receptor overexpressing endothelial cells reduced pro-inflammatory mediators by 60-85%, reduced leukocyte infiltration, doubled re-endothelialisation and cut neointima by 80%, 74% and 95%.
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