Immunological demyelination enhances nerve regeneration after acute transection injury in the adult rat sciatic nerve.
RatOtherSprague-DawleyFemalen = n = 20 rats; 5 harvested at 1 month and 5 at 2 monthsSingle epineural injectionImmediately after transection injury
Model: Sciatic nerve transection injury with reapproximation
A single epineural injection produced demyelination followed by Schwann cell remyelination, and at 2 months significantly increased total axon count, axon density and fibre diameter compared with reapproximation alone.
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