Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide.
RatTBIWeight-drop / impact-accelerationSprague-DawleyMaleIntranasal20 mg/kgImmediately after traumatic brain injury
Model: Weight-drop traumatic brain injury causing cortical and hippocampal neuronal death
Intranasal NAD+ protected neurons in hippocampal CA1, CA3 and dentate gyrus but not in the cortex, and reduced delayed microglial activation at 7 days; superoxide production and PARP-1 accumulation were unaffected.
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