Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome.
RatFractureTibiaSprague Dawley (Simonsen Laboratories)Malen = Groups of 6 to 10 rats; sciatic nerve stimulation experimen…Intraperitoneal20 mg/kg/day intraperitoneally; 30 to 40 mg/kg intraperiton…Given for 8 days before euthanasia at the end of the 4-week cast period; in the…
Model: Distal tibia fracture created with modified pliers followed by 4 weeks of hindlimb cast immobilisation (rat model of complex regional pain syndrome type I)
Fracture produced a roughly fourfold increase in dermal mast cell number and a 250 per cent increase in degranulation; LY303870 completely reversed the fracture-induced increase in mast cell number and neurokinin-1 receptor expression and blocked mast cell degranulation and nociceptive sensitisatio…
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