Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: the effect of minocycline.
MouseTBIClosed-head / concussionSwissMaleIntraperitoneal90 mg/kg at 5 min, then 45 mg/kg at 3 h and 9 hFirst dose 5 min after injury
Model: Closed-head traumatic brain injury by mechanical percussion under anaesthesia
Closed-head injury produced a recognition memory deficit persisting to at least 13 weeks with no clear change in anxiety; minocycline attenuated the memory impairment in an effective and lasting manner.
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