MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.
MouseIschaemia-reperfusionRenalC57BL/6 wild-type and p53 knockoutIntraperitoneal
Model: Postischaemic (ischaemia-reperfusion) acute kidney injury
Nutlin-3a impaired tubular cell regeneration in a p53-dependent manner, but also prevented tubular necrosis by suppressing early sterile inflammation in a p53-independent manner, indicating that MDM2 has both proinflammatory and pro-regenerative roles in acute kidney injury.
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