The delayed post-injury administration of soluble Fas receptor attenuates post-traumatic neural degeneration and enhances functional recovery after traumatic cervical spinal cord injury.
RatSpinal cord injuryContusionWistarfemaleintrathecal cathetertreatment initiated 8 h or 24 h after injury
Model: C7-T1 moderately severe clip compression/contusion cervical spinal cord injury
Treatment started 8 h after injury improved behavioural recovery with greater cell survival, peri-lesional tissue sparing and better preserved descending tracts, while 24 h delayed treatment gave more modest behavioural gains but consistent histological improvement.
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