Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawleyfemalen = 40 rats in total; bpV(pic) n=14, vehicle n=12, sham n=14, w…intraperitoneal400 micrograms/kgimmediately after surgery and injury
Model: moderate unilateral cervical (C5) contusive spinal cord injury with dura intact using the NYU MASCIS impactor (2.5 mm tip, 10 g weight, 12.5 mm height)
bpV(pic) reduced lesion volume and cavitation, spared motor neurons and grey matter vasculature and improved forelimb function at 6 weeks, with restored p-Akt, increased p-S6 and a lower LC3 II/LC3 I ratio at 1 day.
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