Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice.
MouseTBIControlled cortical impact3xTg-AD (PS1M146V knockin, APPswe and TauP301L)both sexesn = 9 D-JNKi1-treated and 8 D-TAT-treated mice, under an option…intracerebroventricular injection into the right lateral ventricle, infused at 0.3 microlitres/min5 micrograms in 5 microlitres of PBS with 0.1% DMSOimmediately after controlled cortical impact
Model: controlled cortical impact traumatic brain injury through a 5 mm craniotomy, 3.0 mm tip centred 3.0 mm anterior to lambda and 2.7 mm left of midline, impact 2.0 mm below the dura
D-JNKi1 reduced phospho-c-jun immunoreactivity by about 40% and axonal accumulation of total tau, pS199 tau and PHF1 tau, but did not change APP-positive axonal varicosities or pT231 tau.
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