Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury.
MouseChemical/toxinC57BL/6 wild type and ACE2 knockoutmale wild type and male ACE2 knockout, with female comparison groupsintraperitoneal2 mg/kgadministered over the 21 days following intratracheal bleomycin; exact start ti…
Model: bleomycin-induced acute lung injury and fibrosis, bleomycin 1.5 U/kg in 50 microlitres intratracheally, controls receiving 50 microlitres sterile 0.9% saline
rhACE2 improved survival, exercise capacity and lung function and reduced collagen deposition and profibrotic and inflammatory mediators after bleomycin, whereas ACE2 deletion worsened fibrosis, more so in males than females.
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