Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction.
RatOtherWistar-Kyoto recipients with syngeneic Wistar-Kyoto donors for the platelet gelfemale recipients, male donorsn = 78 female Wistar-Kyoto rats in total; the angiogenesis PCR…intramyocardial injection with a 29G needle150 microlitres of platelet gel (75 microlitres host plasma…immediately after coronary ligation
Model: acute myocardial infarction by permanent ligation of the left anterior descending coronary artery through a left thoracotomy
Platelet gel preserved ejection fraction over 6 weeks whereas it fell in vehicle controls, and reduced ventricular dilation, wall thinning, apoptosis and myocyte hypertrophy while increasing capillary density and c-kit positive cell numbers.
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