Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawleymaletransplantation into the contusion epicentre1.0 x 10^6 PKH26-labelled mesenchymal stem cells3 days after contusion
Model: T9-T10 contusion spinal cord injury
Mesenchymal stem cell transplantation shifted macrophages from M1 to M2, raised IL-4 and IL-13 and lowered TNF-alpha and IL-6, and was associated with locomotor recovery, axon preservation, less scar tissue and greater myelin sparing.
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