BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure.
RatOtherWistarIntraperitoneal or in drinking water10 micrograms/kg or 10 nanograms/kg
Model: Combined oesophagitis and sphincter failure procedure (insertion of tubes into the lower oesophageal and pyloric sphincters) and bile duct ligation acute pancreatitis, alone and combined; parallel oesophageal manometry in acute pancreatitis patients
The acute pancreatitis procedure produced oesophagitis and failure of both sphincters with reduced pressure at 24 hours, and bile duct ligation alone immediately reduced pressure in both sphincters. Conversely the oesophagitis and sphincter failure procedure produced acute pancreatitis, and combini…
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