Alterations in recovery from spinal cord injury in rats treated with recombinant human bone morphogenetic protein-2 for posterolateral arthrodesis.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemalen = 52 rats underwent T10 dorsal hemisection, with 24 in the ve…Posterolateral spinal application at the level of the spinal cord injuryAt the time of the T10 dorsal hemisection surgery
Model: T10 dorsal hemisection spinal cord injury with posterolateral spinal application at the level of injury
At one week rhBMP-2-treated rats showed significantly increased reactive astrocyte, macrophage-microglia and fibroblast immunoreactivity around the lesion and increased chondroitin sulfate proteoglycan staining relative to controls, with similar differences persisting at six weeks. Acutely, rhBMP-2…
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