The guidance receptor neogenin promotes pulmonary inflammation during lung injury.
MouseOtherNeo1(-/-) and wild-type mice; bone marrow chimerasInjection (route not stated)
Model: Ventilator-associated acute lung injury with neutrophil migration into the alveolar space; in vitro transmigration across HMEC-1 endothelial and A549 alveolar monolayers
Neo1(-/-) mice showed 59% lower alveolar cell count, 41% lower TNF-alpha and 76% lower IL-6 during lung injury. Neo1(-/-) bone marrow chimeras showed 42% reduction in cell count. Antibody-mediated inhibition of neogenin reproduced the reduction in alveolar inflammation.
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