Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice.
MouseChemical/toxinBALB/c and nude miceIntrasplenic injection for cells; intraperitoneal injection for secreted proteinsAfter carbon tetrachloride-induced injury
Model: Carbon tetrachloride-induced acute liver injury
Hepatocyte-like cells showed features of normal hepatocytes, engrafted efficiently and retained hepatic characteristics, promoted host hepatocyte proliferation and revascularisation of injured liver. Injection of the secreted proteins alone produced significant tissue regeneration without cell graf…
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