Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Male and femaleAt resuscitation from cardiac arrest
Model: Asphyxial cardiac arrest induced by 9 minutes of asphyxia followed by resuscitation, producing global cerebral ischaemia
Polynitroxyl albumin reduced early hyperaemia at 5 minutes after arrest whereas albumin markedly increased and prolonged it; delayed cerebral blood flow was comparable across groups. Both agents improved water maze performance versus normal saline, but only in males. Hippocampal neuron survival did…
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