Simvastatin pretreatment prevents ambient particle-induced lung injury in mice.
MouseChemical/toxinBALB/cMaleIntraperitoneal1 mg/kg body weight per dayPretreatment for 14 days before particulate exposure
Model: Acute intranasal exposure to residual oil fly ash or Buenos Aires urban air particulate matter at 1 mg/kg body weight for 24 hours, producing acute lung injury
Both particulate types produced acute pulmonary injury with increased lavage cell number, neutrophilic influx, superoxide anion generation and TNF-alpha. Simvastatin had no significant effect by itself but prevented the pulmonary cytotoxicity and inflammation induced by both particulate types.
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